Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reducing Senescent Cell Burden in Aging and Disease.

Trends in molecular medicine - 1 Jul 2020

Pignolo Robert J, Passos João F, Khosla Sundeep, Tchkonia Tamara, Kirkland James L

Abstract excerpt

Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, and alterations in DNA and chromatin. In preclinical aging models, accumulation of senescent cells is associated with multiple chronic diseases and disorders, geriatric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apoptosis
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circadian rhythm and melatonin

Share to Genetics, Aging, and Longevity in Model Organisms

Share to Mitochondrial Diseases

Share to Phenotype

Share to Telomeres, Telomerase, and Senescence

Source

Open in PubMed Open full text

Identifiers

PMID: 32589933
DOI: 10.1016/j.molmed.2020.03.005
PMCID: PMC7857028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reducing Senescent Cell Burden in Aging and Disease.PMID 32589933Read ↗

Cellular senescence: a key therapeutic target in aging and diseasesSemantic proximity Read ↗

Targeting senescent cells for a healthier longevity: the roadmap for an era of global agingSemantic proximity Read ↗

Cellular Senescence: A Translational Perspective.Semantic proximity Read ↗

Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging InterventionsSemantic proximity Read ↗

Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical TranslationSemantic proximity Read ↗

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.Semantic proximity Read ↗

Focus on senescence: Clinical significance and practical applicationsSemantic proximity Read ↗

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases.Semantic proximity Read ↗

Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic TechnologiesSemantic proximity Read ↗

Discovery, development, and future application of senolytics: theories and predictions.Semantic proximity Read ↗

Targeting cellular senescence with senotherapeutics: senolytics and senomorphicsSemantic proximity Read ↗

Senopathies-Diseases Associated with Cellular Senescence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.