Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation.

doi:10.1038/s41467-023-36193-w

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Article

Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation.

Nature communications - 3 Feb 2023

Boy Maxime, Bisio Valeria, Zhao Lin-Pierre, Guidez Fabien, Schell Bérénice, Lereclus Emilie, Henry Guylaine, Villemonteix Juliette, Rodrigues-Lima Fernando, Gagne Katia, Retiere Christelle, Larcher Lise, Kim Rathana, Clappier Emmanuelle, Sebert Marie, Mekinian Arsène, Fain Olivier, Caignard Anne, Espeli Marion, Balabanian Karl, Toubert Antoine, Fenaux Pierre, Ades Lionel, Dulphy Nicolas

Abstract excerpt

Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders, representing high risk of progression to acute myeloid leukaemia, and frequently associated to somatic mutations, notably in the epigenetic regulator TET2. Natural Killer (NK) cells play a role in the anti-leukemic immune response via their cytolytic activity. Here we show that patients with MDS clones harbouring mutations in the TET2 gene are...

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Identifiers

PMID: 36737440
DOI: 10.1038/s41467-023-36193-w
PMCID: PMC9898569

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