Article
Linking the KIR phenotype with STAT3 and TET2 mutations to identify chronic lymphoproliferative disorders of NK cells.
Blood - 10 Jun 2021
Pastoret Cédric, Desmots Fabienne, Drillet Gaëlle, Le Gallou Simon, Boulland Marie-Laure, Thannberger Alexia, Doncker Anne-Violaine, Salaun Véronique, Damaj Gandhi Laurent, Veyrat-Masson Richard, Tournilhac Olivier, Moignet Aline, Pangault Céline, Roussel Mikaël, Fest Thierry, Lamy Thierry
Abstract excerpt
Distinguishing chronic lymphoproliferative disorders of NK cells (CLPD-NK) from reactive NK-cell expansion is challenging. We assessed the value of killer immunoglobulin-like receptor(KIR) phenotyping and targeted high-throughput sequencing in a cohort of 114 consecutive patients with NK cell proliferation, retrospectively assigned to a CLPD-NK group (n = 46) and a reactive NK group (n = 68). We then developed an...
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