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Article

Mutation of ten-eleven translocation-2 is associated with increased risk of autoimmune disease in patients with myelodysplastic syndrome.

The Korean journal of internal medicine - 1 Mar 2020

Oh Yoon-Jeong, Shin Dong-Yeop, Hwang Sang Mee, Kim Sung-Min, Im Kyongok, Park Hee Sue, Kim Jung-Ah, Song Yeong Wook, Márquez Ana, Martín Javier, Lee Dong-Soon, Park Jin Kyun

Abstract excerpt

BACKGROUND/AIMS: Myelodysplastic syndrome (MDS) is caused by genetic and epigenetic alteration of hematopoietic precursors and immune dysregulation. Approximately 20% of patients with MDS develop an autoimmune disease (AID). Here, we investigated whether particular genetic mutations are associated with AID in patients with MDS. METHODS: Eighty-eight genetic mutations associated with myeloid malignancy were...

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Identifiers

PMID: 31640337
DOI: 10.3904/kjim.2018.247
PMCID: PMC7061008

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