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Article

Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias.

Blood - 26 Aug 2021

Olson Thomas L, Cheon HeeJin, Xing Jeffrey C, Olson Kristine C, Paila Umadevi, Hamele Cait E, Neelamraju Yaseswini, Shemo Bryna C, Schmachtenberg Matt, Sundararaman Shriram K, Toro Mariella F, Keller Cheryl A, Farber Emily A, Onengut-Gumuscu Suna, Garrett-Bakelman Francine E, Hardison Ross C, Feith David J, Ratan Aakrosh, Loughran Thomas P

Abstract excerpt

Chronic natural killer large granular lymphocyte (NK-LGL) leukemia, also referred to as chronic lymphoproliferative disorder of NK cells, is a rare disorder defined by prolonged expansion of clonal NK cells. Similar prevalence of STAT3 mutations in chronic T-LGL and NK-LGL leukemia is suggestive of common pathogenesis. We undertook whole-genome sequencing to identify mutations unique to NK-LGL leukemia. The...

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Identifiers

PMID: 33786584
DOI: 10.1182/blood.2020005831
PMCID: PMC8394905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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