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Therapy-related myeloid neoplasms with normal karyotype show distinct genomic and clinical characteristics compared to their counterparts with abnormal karyotype.

British journal of haematology - 1 Jun 2022

Tariq Hamza, Barnea Slonim Liron, Coty Fattal Zachary, Alikhan Mir B, Segal Jeremy, Gurbuxani Sandeep, Helenowski Irene B, Zhang Hui, Sukhanova Madina, Lu Xinyan, Altman Jessica K, Chen Qing C, Behdad Amir

Abstract excerpt

Therapy-related myeloid neoplasms (t-MNs) are a complication of treatment with cytotoxic chemotherapy and/or radiation therapy. The majority of t-MNs show chromosomal abnormalities associated with myelodysplastic syndrome (MDS) or KMT2A rearrangements and are characterized by poor clinical outcomes. A small but substantial subset of patients have normal karyotype (NK) and their clinical characteristics and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35304738
DOI: 10.1111/bjh.18154

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