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Spatial Mapping of Hematopoietic Clones in Human Bone Marrow.

Blood cancer discovery - 1 May 2024

Young Andrew L, Davis Hannah C, Cox Maggie J, Parsons Tyler M, Burkart Samantha C, Bender Diane E, Sun Lulu, Oh Stephen T, Challen Grant A

Abstract excerpt

Clonal hematopoiesis (CH) is the expansion of somatically mutated cells in the hematopoietic compartment of individuals without hematopoietic dysfunction. Large CH clones (i.e., >2% variant allele fraction) predispose to hematologic malignancy, but CH is detected at lower levels in nearly all middle-aged individuals. Prior work has extensively characterized CH in peripheral blood, but the spatial distribution of...

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Identifiers

PMID: 38421682
DOI: 10.1158/2643-3230.BCD-23-0110
PMCID: PMC11062237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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