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Article

Chromosomal Aberrations Accumulate during Metastasis of Virus-Negative Merkel Cell Carcinoma.

The Journal of investigative dermatology - 1 Jul 2023

Robb Tamsin J, Ward Zoe, Houseman Pascalene, Woodhouse Braden, Patel Rachna, Fitzgerald Sandra, Tsai Peter, Lawrence Ben, Parker Kate, Print Cristin G, Blenkiron Cherie

Abstract excerpt

Merkel cell carcinoma is a rare, aggressive skin tumor initiated by polyomavirus integration or UV light DNA damage. In New Zealand, there is a propensity toward the UV-driven form (31 of 107, 29% virus positive). Using archival formalin-fixed, paraffin-embedded tissues, we report targeted DNA sequencing covering 246 cancer genes on 71 tumor tissues and 38 nonmalignant tissues from 37 individuals, with 33 of 37...

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Identifiers

PMID: 36736454
DOI: 10.1016/j.jid.2023.01.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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