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Article

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas.

Cancer research - 15 Dec 2015

Wong Stephen Q, Waldeck Kelly, Vergara Ismael A, Schröder Jan, Madore Jason, Wilmott James S, Colebatch Andrew J, De Paoli-Iseppi Ricardo, Li Jason, Lupat Richard, Semple Timothy, Arnau Gisela Mir, Fellowes Andrew, Leonard J Helen, Hruby George, Mann Graham J, Thompson John F, Cullinane Carleen, Johnston Meredith, Shackleton Mark, Sandhu Shahneen, Bowtell David D L, Johnstone Ricky W, Fox Stephen B, McArthur Grant A, Papenfuss Anthony T, Scolyer Richard A, Gill Anthony J, Hicks Rodney J, Tothill Richard W

Abstract excerpt

Merkel cell carcinoma (MCC) is an uncommon, but highly malignant, cutaneous tumor. Merkel cell polyoma virus (MCV) has been implicated in a majority of MCC tumors; however, viral-negative tumors have been reported to be more prevalent in some geographic regions subject to high sun exposure. While the impact of MCV and viral T-antigens on MCC development has been extensively investigated, little is known about the...

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Source

Identifiers

PMID: 26627015
DOI: 10.1158/0008-5472.CAN-15-1877

Genes

MCC
AKT1
FAT1
FGFR2
HRAS
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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