Article
Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2016
Harms Paul W, Collie Angela M B, Hovelson Daniel H, Cani Andi K, Verhaegen Monique E, Patel Rajiv M, Fullen Douglas R, Omata Kei, Dlugosz Andrzej A, Tomlins Scott A, Billings Steven D
Abstract excerpt
Merkel cell carcinoma is a rare but highly aggressive cutaneous neuroendocrine carcinoma. Cytokeratin 20 (CK20) is expressed in ~95% of Merkel cell carcinomas and is useful for distinction from morphologically similar entities including metastatic small-cell lung carcinoma. Lack of CK20 expression may make diagnosis of Merkel cell carcinoma more challenging, and has unknown biological significance. Approximately...
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