Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism.

doi:10.1093/ecco-jcc/jjz213

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Article

Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism.

Journal of Crohn's & colitis - 19 Jun 2020

Cardinale Christopher J, March Michael E, Lin Xiang, Liu Yichuan, Spruce Lynn A, Bradfield Jonathan P, Wei Zhi, Seeholzer Steven H, Grant Struan F A, Hakonarson Hakon

Abstract excerpt

BACKGROUND AND AIMS: Among the >240 genetic loci described to date which confer susceptibility to inflammatory bowel disease, a small subset have been fine-mapped to an individual, non-coding single nucleotide polymorphism [SNP]. To illustrate a model mechanism by which a presumed-causal non-coding SNP can function, we analysed rs1887428, located in the promoter region of the Janus kinase 2 [JAK2] gene. METHODS:...

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PMID: 32271392
DOI: 10.1093/ecco-jcc/jjz213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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