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Article

Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.

British journal of cancer - 1 Apr 2023

Ishino Takamasa, Kawashima Shusuke, Tanji Etsuko, Ueno Toshihide, Ueda Youki, Ogasawara Sadahisa, Sato Kazuhito, Mano Hiroyuki, Ishihara Soichiro, Kato Naoya, Kawazu Masahito, Togashi Yosuke

Abstract excerpt

BACKGROUND: Identifying biomarkers to predict immune checkpoint inhibitor (ICI) efficacy is warranted. Considering that somatic mutation-derived neoantigens induce strong immune responses, patients with a high tumour mutational burden reportedly tend to respond to ICIs. However, there are several conflicting data. Therefore, we focused on the original function of neoantigenic mutations and their impact on the...

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Identifiers

PMID: 36732592
DOI: 10.1038/s41416-023-02165-6
PMCID: PMC10006227

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