Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex.

doi:10.1007/s00401-023-02541-9

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Article

Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex.

Acta neuropathologica - 1 Apr 2023

Matosin Natalie, Arloth Janine, Czamara Darina, Edmond Katrina Z, Maitra Malosree, Fröhlich Anna S, Martinelli Silvia, Kaul Dominic, Bartlett Rachael, Curry Amber R, Gassen Nils C, Hafner Kathrin, Müller Nikola S, Worf Karolina, Rehawi Ghalia, Nagy Corina, Halldorsdottir Thorhildur, Cruceanu Cristiana, Gagliardi Miriam, Gerstner Nathalie, Ködel Maik, Murek Vanessa, Ziller Michael J, Scarr Elizabeth, Tao Ran, Jaffe Andrew E, Arzberger Thomas, Falkai Peter, Kleinmann Joel E, Weinberger Daniel R, Mechawar Naguib, Schmitt Andrea, Dean Brian, Turecki Gustavo, Hyde Thomas M, Binder Elisabeth B

Abstract excerpt

Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a subset of psychiatric patients, with potential to be leveraged as a therapeutic target for these individuals. While it is widely reported that FKBP5/FKBP51 mRNA/protein (FKBP5/1) expression is impacted by psychiatric disease...

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PMID: 36729133
DOI: 10.1007/s00401-023-02541-9
PMCID: PMC10020280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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