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Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

28 Apr 2014

Abstract excerpt

Etoposide is a topoisomerase II poison that is utilized to treat a broad spectrum of human cancers. Despite its wide clinical use, 2-3% of patients treated with etoposide eventually develop treatment-related acute myeloid leukemias (t-AMLs) characterized by rearrangements of the MLL gene. The molecular basis underlying the development of these t-AMLs is not well understood; however, previous studies have...

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PMID: 24766193
DOI: 10.1021/bi500421q

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