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Article

The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells.

Leukemia - 1 Apr 2023

Staehle Anne Marie, Peeken Jan Caspar, Vladimirov Georg, Hoeness Mirjam Elisabeth, Bojtine Kovacs Sarolta, Karantzelis Nikolaos, Gruender Albert, Koellerer Christoph, Jutzi Jonas Samuel, Pahl Heike Luise, Staehle Hans Felix

Abstract excerpt

The transcription factor NFE2 is overexpressed in most patients with myeloproliferative neoplasms (MPN). Moreover, mutations in NFE2, found in a subset of MPN patients, strongly predispose for transformation to acute leukemia. Transgenic mice overexpressing NFE2 as well as mice harboring NFE2 mutations display an MPN phenotype and spontaneously develop leukemia. However, the molecular mechanisms effecting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36709354
DOI: 10.1038/s41375-023-01826-y
PMCID: PMC10079541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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