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MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus

10 May 2022

Abstract excerpt

Rearrangements that drive ectopic MEF2C expression have recurrently been found in patients with human early thymocyte progenitor acute lymphoblastic leukemia (ETP-ALL). Here, we show high levels of MEF2C expression in patients with ETP-ALL. Using both in vivo and in vitro models of ETP-ALL, we demonstrate that elevated MEF2C expression blocks NOTCH-induced T cell differentiation while promoting a B-lineage...

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PMID: 35536646
DOI: 10.1172/jci.insight.150363

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