Article
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.
The Journal of experimental medicine - 6 May 2013
Jutzi Jonas S, Bogeska Ruzhica, Nikoloski Gorica, Schmid Corina A, Seeger Thalia S, Stegelmann Frank, Schwemmers Sven, Gründer Albert, Peeken Jan C, Gothwal Monika, Wehrle Julius, Aumann Konrad, Hamdi Kamar, Dierks Christine, Kamar Wang Wei, Döhner Konstanze, Jansen Joop H, Pahl Heike L
Abstract excerpt
The molecular etiology of myeloproliferative neoplasms (MPNs) remains incompletely understood, despite recent advances incurred through the discovery of several different mutations in MPN patients. We have recently described overexpression of the transcription factor NF-E2 in MPN patients and shown that elevated NF-E2 levels in vivo cause an MPN phenotype and predispose to leukemic transformation in transgenic...
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