A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

doi:10.1084/jem.20110540

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

The Journal of experimental medicine - 16 Jan 2012

Kaufmann Kai B, Gründer Albert, Hadlich Tobias, Wehrle Julius, Gothwal Monika, Bogeska Ruzhica, Seeger Thalia S, Kayser Sarah, Pham Kien-Binh, Jutzi Jonas S, Ganzenmüller Lucas, Steinemann Doris, Schlegelberger Brigitte, Wagner Julia M, Jung Manfred, Will Britta, Steidl Ulrich, Aumann Konrad, Werner Martin, Günther Thomas, Schüle Roland, Rambaldi Alessandro, Pahl Heike L

Abstract excerpt

The molecular pathophysiology of myeloproliferative neoplasms (MPNs) remains poorly understood. Based on the observation that the transcription factor NF-E2 is often overexpressed in MPN patients, independent of the presence of other molecular aberrations, we generated mice expressing an NF-E2 transgene in hematopoietic cells. These mice exhibit many features of MPNs, including thrombocytosis, leukocytosis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Cell Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Cells

Share to Chromatin

Share to Disease Progression

Share to Hematopoietic Stem Cells

Share to Histone Deacetylase Inhibitors

Share to Leukemia

Share to Myeloproliferative Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 22231305
DOI: 10.1084/jem.20110540
PMCID: PMC3260873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.PMID 22231305Read ↗

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.Semantic proximity Read ↗

AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2Semantic proximity Read ↗

The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells.Semantic proximity Read ↗

In vivo ablation of NF-κB cascade effectors alleviates disease burden in myeloproliferative neoplasmsSemantic proximity Read ↗

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.Semantic proximity Read ↗

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrationsSemantic proximity Read ↗

RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.Semantic proximity Read ↗

Loss of <i>Ezh2</i> synergizes with <i>JAK2</i> -V617F in initiating myeloproliferative neoplasms and promoting myelofibrosisSemantic proximity Read ↗

Murine Modeling of Myeloproliferative Neoplasms.Semantic proximity Read ↗

[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis].Semantic proximity Read ↗

Successful hematopoietic cell transplantation in patients with unique NF-κB essential modulator (NEMO) mutations.Semantic proximity Read ↗

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.