Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression

4 May 2020

Abstract excerpt

Proteasomes are protease complexes essential for cellular homeostasis, and their activity is crucial for cancer cell growth. However, the mechanism of how proteasome activity is maintained in cancer cells has remained unclear. The CNC family transcription factor NFE2L1 induces the expression of almost all proteasome-related genes under proteasome inhibition. Both NFE2L1 and its phylogenetically closest homolog,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress and Disease
Share to Peptidase Inhibition and Analysis
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32366381
DOI: 10.1128/mcb.00010-20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational RepressionPMID 32366381Read ↗

NRF1 and NRF3 complementarily maintain a basal proteasome activity in cancer cells through CPEB3-mediated translational repressionSemantic proximity Read ↗

A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradationSemantic proximity Read ↗

Unravelling the role of NFE2L1 in stress responses and related diseasesSemantic proximity Read ↗

NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma ProteinSemantic proximity Read ↗

Function expansion of antitumor transcriptional activator NFE2L1 by the original discovery of its non-transcription factor activitySemantic proximity Read ↗

Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1.Semantic proximity Read ↗

Identifying the Ubiquitin Ligase Complex That Regulates the NF1 Tumor Suppressor and RasSemantic proximity Read ↗

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.Semantic proximity Read ↗

Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of CancerSemantic proximity Read ↗

WWC proteins–mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of functionSemantic proximity Read ↗

Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin SignalingSemantic proximity Read ↗

MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.