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Article

Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2V617F-driven myeloproliferative disease initiation in mice.

PloS one - 1 Jan 2020

Staehle Hans F, Heinemann Johannes, Gruender Albert, Omlor Anne M, Pahl Heike Luise, Jutzi Jonas Samuel

Abstract excerpt

The histone demethylase JMJD1C is overexpressed in patients with myeloproliferative neoplasms (MPNs) and has been implicated in leukemic stem cell function of MLL-AF9 and HOXA9-driven leukemia. In the emerging field of histone demethylase inhibitors, JMJD1C therefore became a potential target. Depletion of Jmjd1c expression significantly reduced cytokine-independent growth in an MPN cell line, indicating a role...

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Identifiers

PMID: 32017785
DOI: 10.1371/journal.pone.0228362
PMCID: PMC6999878

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