Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.

Blood - 3 May 2018

Peeken Jan C, Jutzi Jonas S, Wehrle Julius, Koellerer Christoph, Staehle Hans F, Becker Heiko, Schoenwandt Elias, Seeger Thalia S, Schanne Daniel H, Gothwal Monika, Ott Christopher J, Gründer Albert, Pahl Heike L

Abstract excerpt

The transcription factor "nuclear factor erythroid 2" (NFE2) is overexpressed in the majority of patients with myeloproliferative neoplasms (MPNs). In murine models, elevated NFE2 levels cause an MPN phenotype with spontaneous leukemic transformation. However, both the molecular mechanisms leading to NFE2 overexpression and its downstream targets remain incompletely understood. Here, we show that the histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histones
Share to Chromobox Protein Homolog 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Decitabine

Share to Janus Kinase 2

Share to Jumonji Domain-Containing Histone Demethylases

Share to Myeloproliferative Disorders

Share to Oxidoreductases, N-Demethylating

Share to Polycythemia Vera

Source

Open in PubMed Open full text

Identifiers

PMID: 29519804
DOI: 10.1182/blood-2017-10-810622
PMCID: PMC5934799

Genes

NFE2
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.PMID 29519804Read ↗

The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells.Semantic proximity Read ↗

AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2Semantic proximity Read ↗

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.Semantic proximity Read ↗

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.Semantic proximity Read ↗

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibitionSemantic proximity Read ↗

PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN.Semantic proximity Read ↗

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrationsSemantic proximity Read ↗

RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.Semantic proximity Read ↗

DNA polymerase kappa stabilized by PTBP2 interacts with MRE11 and promotes genomic instability in leukemia cellsSemantic proximity Read ↗

Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasmSemantic proximity Read ↗

Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2V617F-driven myeloproliferative disease initiation in mice.Semantic proximity Read ↗

Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.