Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production

27 Jan 2023

Abstract excerpt

Abstract Improving the cellular capacity of Chinese hamster ovary (CHO) cells to produce large amounts of therapeutic proteins remains a major challenge for the biopharmaceutical industry. In previous studies, we observed strong correlations between the performance of CHO cells and expression of two transcription factors (TFs), MYC and XBP1s. Here, we have evaluated the effective of overexpression of these two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36707606
DOI: 10.1038/s41598-023-28622-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO productionPMID 36707606Read ↗

Combined gene and environmental engineering offers a synergetic strategy to enhance r‐protein production in Chinese hamster ovary cellsSemantic proximity Read ↗

Decoupling Growth and Protein Production in CHO Cells: A Targeted ApproachSemantic proximity Read ↗

Transcriptional profiling of phenotypically different Epo-Fc expressing CHO clones by cross-species microarray analysis.Semantic proximity Read ↗

Identification of Autocrine Growth Factors Secreted by CHO Cells for Applications in Single-Cell Cloning MediaSemantic proximity Read ↗

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteinsSemantic proximity Read ↗

Evaluating apoptotic gene efficiency for CHO culture performance using targeted integrationSemantic proximity Read ↗

Transcriptome analysis of EPO and GFP HEK293 Cell-lines Reveal Shifts in Energy and ER Capacity Support Improved Erythropoietin Production in HEK293F CellsSemantic proximity Read ↗

Repressing expression of difficult‐to‐express recombinant proteins during the selection process increases productivity of CHO stable poolsSemantic proximity Read ↗

Manipulating gene expression levels in mammalian cell factories: An outline of synthetic molecular toolboxes to achieve multiplexed controlSemantic proximity Read ↗

Nature as blueprint: Global phenotype engineering of CHO production cells based on a multi-omics comparison with plasma cellsSemantic proximity Read ↗

miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering.Semantic proximity Read ↗

How to train your cell - Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.