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Identification of Autocrine Growth Factors Secreted by CHO Cells for Applications in Single-Cell Cloning Media

13 Jun 2013

Abstract excerpt

Chinese hamster ovary (CHO) cell lines are widely used for the expression of therapeutic recombinant proteins, including monoclonal antibodies and other biologics. For manufacturing, cells derived from a single-cell clone are typically used to ensure product consistency. Presently, fetal bovine serum (FBS) is commonly used to support low cell density cultures to obtain clonal cell populations because cells grow...

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PMID: 23763710
DOI: 10.1021/pr400352n

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