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Combined gene and environmental engineering offers a synergetic strategy to enhance r‐protein production in Chinese hamster ovary cells

25 Nov 2021

Abstract excerpt

Abstract Environmental growth‐inhibition conditions (GICs) have been used extensively for increasing cell‐specific productivity (qP) of Chinese hamster ovary (CHO) cells, with the most common being temperature downshift and sodium butyrate (NaBu) treatment. B lymphocyte‐induced maturation protein‐1 (BLIMP1) overexpression in CHO cells can also inhibit cell growth and increase product titers and qP. Given the...

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PMID: 34821376
DOI: 10.1002/bit.28000

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