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Repressing expression of difficult‐to‐express recombinant proteins during the selection process increases productivity of CHO stable pools

26 May 2023

Abstract excerpt

More than half of licensed therapeutic recombinant proteins (r-proteins) are manufactured using constitutively-expressing, stably-transfected Chinese hamster ovary (CHO) clones. While constitutive CHO expression systems have proven their efficacy for the manufacturing of monoclonal antibodies, many next-generation therapeutics such as cytokines and bispecific antibodies as well as biological targets such as...

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PMID: 37232536
DOI: 10.1002/bit.28435

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