Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos.

doi:10.1158/2767-9764.CRC-22-0149

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Article

Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos.

Cancer research communications - 1 Nov 2022

Toal Ted W, Estrada-Florez Ana P, Polanco-Echeverry Guadalupe M, Sahasrabudhe Ruta M, Lott Paul C, Suarez-Olaya John J, Guevara-Tique Alix A, Rocha Sienna, Morales-Arana Alexa, Castro-Valencia Fabian, Urayama Shiro, Kirane Amanda, Wei Dongguang, Rios-Sarabia Nora, Medrano Rafael, Mantilla Alejandra, Echeverry de Polanco Magdalena, Torres Javier, Bohorquez-Lozano Mabel E, Carvajal-Carmona Luis G

Abstract excerpt

Gastric cancer is a leading cause of cancer mortality and health disparities in Latinos. We evaluated gastric intratumoral heterogeneity using multiregional sequencing of >700 cancer genes in 115 tumor biopsies from 32 patients, 29 who were Latinos. Analyses focused on comparisons with The Cancer Genome Atlas (TCGA) and on mutation clonality, druggability, and signatures. We found that only approximately 30% of...

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PMID: 36970058
DOI: 10.1158/2767-9764.CRC-22-0149
PMCID: PMC10035402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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