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Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations

27 Dec 2022

Abstract excerpt

Multiple clinical trials exploring the potential of adoptive natural killer (NK) cell therapy for cancer have employed ex vivo expansion using feeder cells to obtain large numbers of NK cells. We have previously utilized the rhesus macaque model to clonally track the NK cell progeny of barcode-transduced CD34 + stem and progenitor cells after transplant. In this study, NK cells from barcoded rhesus macaques were...

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PMID: 36699615
DOI: 10.1016/j.omto.2022.12.006

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