Article
Estrogen/Progesterone Receptor Loss, CTNNB1 and KRAS Mutations Are Associated With Local Recurrence or Distant Metastasis in Low-Grade Endometrial Endometrioid Carcinoma.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Mar 2023
Chibbar Rajni, Foerstner Sabrina, Suresh Janarathnee, Chibbar Richa, Piche Alexandre, Kundapur Deeksha, Kanthan Rani, Kundapur Vijayanand, Lee Cheng Han, Agrawal Anita, Lai Raymond
Abstract excerpt
A subset of endometrial endometrioid carcinomas (EECs) with low-grade histology recur with poor outcomes. Published evidence suggests that poor outcomes may be associated with loss of expression of ER-alpha (ER-α) as well as with β-Catenin-1 ( CTNNB1 ) and Kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutations. This study reports on institutional experience with the incidence of recurrence in low-grade EEC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.