Article
Clinicopathological features and prognostic significance of CTNNB1 mutation in low-grade, early-stage endometrial endometrioid carcinoma.
Virchows Archiv : an international journal of pathology - 1 Dec 2021
Ruz-Caracuel Ignacio, López-Janeiro Álvaro, Heredia-Soto Victoria, Ramón-Patino Jorge L, Yébenes Laura, Berjón Alberto, Hernández Alicia, Gallego Alejandro, Ruiz Patricia, Redondo Andrés, Peláez-García Alberto, Mendiola Marta, Hardisson David
Abstract excerpt
Low-grade and early-stage endometrioid endometrial carcinomas (EECs) have an overall good prognosis but biomarkers identifying patients at risk of relapse are still lacking. Recently, CTNNB1 exon 3 mutation has been identified as a potential risk factor of recurrence in these patients. We evaluate the prognostic value of CTNNB1 mutation in a single-centre cohort of 218 low-grade, early-stage EECs, and the...
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