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USP18 directly regulates Snail1 protein through ubiquitination pathway in colorectal cancer

28 Jul 2020

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is one of the most common digestive malignant tumors in the world. Ubiquitin-specific peptidase 18 (USP18) plays a regulatory role in tumorigenesis, and abnormal expression of Snail1 is also believed to be related to tumorigenesis. However, whether USP18 could affect colorectal cancer through Snail1 remains unclear. This study was designed to investigate the role of USP18 in...

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PMID: 32742193
DOI: 10.1186/s12935-020-01442-1

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