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Usp8 promotes tumor cell migration through activating the JNK pathway

31 Mar 2022

Abstract excerpt

Tumor metastasis is the most cause of high mortality for cancer patients. Identification of novel factors that modulate tumor cell migration is of great significance for therapeutic strategies. Here, we find that the ubiquitin-specific protease 8 (Usp8) promotes tumor cell migration through activating the c-Jun N-terminal kinase (JNK) pathway. Genetic epistasis analyses uncover Usp8 acts upstream of Tak1 to...

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PMID: 35361778
DOI: 10.1038/s41419-022-04749-1

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