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3D genome alterations in T cells associated with disease activity of systemic lupus erythematosus

1 Sept 2022

Abstract excerpt

OBJECTIVES: Three-dimensional (3D) genome alterations can dysregulate gene expression by rewiring physical interactions within chromosomes in a tissue-specific or cell-specific manner and lead to diseases. We aimed to elucidate the 3D genome structure and its role in gene expression networks dysregulated in systemic lupus erythematosus (SLE). METHODS: T cells from 7 patients with SLE and 5 age-matched and...

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PMID: 36690410
DOI: 10.1136/ard-2022-222653

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