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Article

H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus

2 Feb 2016

Abstract excerpt

BACKGROUND: The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chromatin mark of active transcription. Recent studies have suggested that H3K4me3 breadth has an important regulatory role in cell identity. This project examined H3K4me3 breadth at transcription...

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PMID: 26839600
DOI: 10.1186/s13148-016-0179-4

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