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Article

KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes.

Communications biology - 6 Nov 2024

Wang Andrew, Fairhurst Anna-Marie, Liu Kui, Wakeland Benjamin, Barnes Spencer, Malladi Venkat S, Viswanathan Kasthuribai, Arana Carlos, Dozmorov Igor, Singhar Amrita, Du Yong, Imam Marjaan, Moses Angela, Chen Christian, Sunkavalli Ashwini, Casco Jose, Rakheja Dinesh, Li Quan-Zhen, Mohan Chandra, Clayberger Carol, Wakeland Edward K, Khan Shaheen

Abstract excerpt

Although significant progress has been achieved in elucidating the genetic architecture of systemic lupus erythematosus (SLE), identifying genes underlying the pathogenesis has been challenging. The NZM2410-derived lupus susceptibility Sle3 locus is associated with T cell hyperactivity and activated myeloid cells. However, candidate genes associated with these phenotypes have not been identified. Here, we narrow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39506084
DOI: 10.1038/s42003-024-07099-0
PMCID: PMC11541912

Genes

KLF13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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