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Progress and challenges in directing the differentiation of human iPSCs into spinal motor neurons

5 Jan 2023

Abstract excerpt

Motor neuron (MN) diseases, including amyotrophic lateral sclerosis, progressive bulbar palsy, primary lateral sclerosis and spinal muscular atrophy, cause progressive paralysis and, in many cases, death. A better understanding of the molecular mechanisms of pathogenesis is urgently needed to identify more effective therapies. However, studying MNs has been extremely difficult because they are inaccessible in the...

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PMID: 36684437
DOI: 10.3389/fcell.2022.1089970

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