Article

An optimized workflow to generate and characterize iPSC-derived motor neuron (MN) spheroids

2022-09-23

Abstract excerpt

Motor neuron diseases (MNDs) are characterized by the progressive degeneration of motor neurons (MNs) from the cortex, brainstem and/or the spinal cord. In an effort to understand the underlying causes of this selective degeneration, a multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived MNs have been developed. Moreover, different groups have started to use advanced 3D structures, c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4a0b9e8-a818-5b0b-92bd-bb4125f004c4
DOI: 10.1101/2022.09.22.509079

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An optimized workflow to generate and characterize iPSC-derived motor neuron (MN) spheroidsDOI 10.1101/2022.09.22.509079Read

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells.Semantic proximity Read

Progress and challenges in directing the differentiation of human iPSCs into spinal motor neuronsSemantic proximity Read

Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencingSemantic proximity Read

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing.Semantic proximity Read

Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.Semantic proximity Read

Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral SclerosisSemantic proximity Read

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factorsSemantic proximity Read

Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by ImmunostainingSemantic proximity Read

Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in NeurotraumaSemantic proximity Read

iPSCs and Organoids in Advancing Neuropathology Research and TherapiesSemantic proximity Read

Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease.Semantic proximity Read

Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids, and Disease ModelingSemantic proximity Read