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Culture of Human iPSC-Derived Motoneurons in Compartmentalized Microfluidic Devices and Quantitative Assays for Studying Axonal Phenotypes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Garone Maria Giovanna, D'Antoni Chiara, Rosa Alessandro

Abstract excerpt

In order to use induced Pluripotent Stem Cells (iPSCs) to model neurodegenerative diseases, efficient and homogeneous generation of neurons in vitro represents a key step. Here we describe a method to obtain and characterize functional human spinal and cranial motoneurons using a combined approach of microfluidic chips and programs designed for scientific multidimensional imaging. We have used this approach to...

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PMID: 35507162
DOI: 10.1007/978-1-0716-1979-7_12

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