Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel protocol to derive cervical motor neurons from induced pluripotent stem cells for amyotrophic lateral sclerosis

17 Aug 2023

Abstract excerpt

Sporadic amyotrophic lateral sclerosis (sALS) is the majority of ALS, and the lack of appropriate disease models has hindered its research. Induced pluripotent stem cell (iPSC) technology now permits derivation of iPSCs from somatic cells of sALS patients to investigate disease phenotypes and mechanisms. Most existing differentiation protocols are time-consuming or low efficient in generating motor neurons (MNs)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37595581
DOI: 10.1016/j.stemcr.2023.07.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel protocol to derive cervical motor neurons from induced pluripotent stem cells for amyotrophic lateral sclerosisPMID 37595581Read ↗

Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.Semantic proximity Read ↗

Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imagingSemantic proximity Read ↗

Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS PatientsSemantic proximity Read ↗

Progress and challenges in directing the differentiation of human iPSCs into spinal motor neuronsSemantic proximity Read ↗

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factorsSemantic proximity Read ↗

Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALSSemantic proximity Read ↗

Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Motoneuron differentiation of induced pluripotent stem cells from SOD1G93A mice.Semantic proximity Read ↗

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem CellsSemantic proximity Read ↗

Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathySemantic proximity Read ↗

Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.