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Article

Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging

19 Dec 2024

Abstract excerpt

This study introduces a novel method for rapidly and efficiently inducing human spinal lower motor neurons (LMNs) from induced pluripotent stem cells (iPSCs) to eventually elucidate the pathomechanisms of amyotrophic lateral sclerosis (ALS) and facilitate drug screening. Previous methods were limited by low induction efficiency, poor LMN purity, or labor-intensive induction and evaluation processes. Our protocol...

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PMID: 39706179
DOI: 10.1016/j.stemcr.2024.11.007

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