Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Higher-Level Pathway Objectives of Epigenetic Therapy: A Solution to the p53 Problem in Cancer.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting - 1 Jan 2017

Velcheti Vamsidhar, Radivoyevitch Tomas, Saunthararajah Yogen

Abstract excerpt

Searches for effective yet nontoxic oncotherapies are searches for exploitable differences between cancer and normal cells. In its core of cell division, cancer resembles normal life, coordinated by the master transcription factor MYC. Outside of this core, apoptosis and differentiation programs, which dominantly antagonize MYC to terminate cell division, necessarily differ between cancer and normal cells, as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Cell Self Renewal

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to Epigenesis, Genetic

Share to Proto-Oncogene Proteins c-myc

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 28561650
DOI: 10.1200/EDBK_174175

Genes

MYC
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Higher-Level Pathway Objectives of Epigenetic Therapy: A Solution to the p53 Problem in Cancer.PMID 28561650Read ↗

Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells.Semantic proximity Read ↗

Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivationSemantic proximity Read ↗

Importance of p53 for cancer onset and therapy.Semantic proximity Read ↗

DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunitiesSemantic proximity Read ↗

The future of epigenetic therapy in solid tumours—lessons from the pastSemantic proximity Read ↗

Cancer therapy meets p53.Semantic proximity Read ↗

p53 — a Jack of all trades but master of noneSemantic proximity Read ↗

p53 balances between tissue hierarchy and anarchySemantic proximity Read ↗

Cancer Genomics: Restorative Senescence, Transition to Unicellularity, DDR Circuits, and the Status Quo AnteSemantic proximity Read ↗

A matter of life and cell death.Semantic proximity Read ↗

p53 Biology and Reactivation for Improved Therapy in MDS and AML–Are We Building Castles in the Air?Semantic proximity Read ↗

Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.