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Article

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.

Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2010

Mizuno Hideaki, Spike Benjamin T, Wahl Geoffrey M, Levine Arnold J

Abstract excerpt

Breast cancer comprises a heterogeneous set of diseases distinguishable from one another by pathologic presentation and molecular signatures. However, each breast cancer subtype is also heterogeneous. Some of the heterogeneity may be attributable to genetic instability, but recent data emphasize that developmental plasticity may also contribute. The p53 tumor suppressor could constitute a nodal control point...

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Identifiers

PMID: 21149740
DOI: 10.1073/pnas.1017001108
PMCID: PMC3012457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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