Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment

7 Feb 2025

Abstract excerpt

Glioblastoma (GBM) tumors exhibit extensive genomic, epigenomic, and transcriptional diversity, with significant intratumoral heterogeneity, complicating standard treatment approaches involving radiation (RT) and the DNA-alkylating agent temozolomide (TMZ). In this study, we employed an integrative multi-omics approach, including targeted proteomics, transcriptomics, genomics, and DNA methylation profiling, to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Glioma Diagnosis and Treatment
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39919036
DOI: 10.1371/journal.pone.0315171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatmentPMID 39919036Read ↗

Impact of genomic background and developmental state on signaling pathways and response to therapy in glioblastoma patient-derived cellsSemantic proximity Read ↗

Multi‐omic integration of DNA methylation and gene expression data reveals molecular vulnerabilities in glioblastomaSemantic proximity Read ↗

Genome-wide profiling of patient-derived glioblastoma stem-like cells reveals recurrent genetic and transcriptomic signatures associated with brain tumorsSemantic proximity Read ↗

Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted TherapySemantic proximity Read ↗

Mechanisms of Resistance to Current Glioblastoma TherapiesSemantic proximity Read ↗

The functional genomic circuitry of human glioblastoma stem cellsSemantic proximity Read ↗

Mapping the Stemness Landscape of Glioblastoma to Drive Heterogeneity and Drug Resistance: Bridging Pathological Omics with Prognostic OutcomesSemantic proximity Read ↗

Exploring Responses of Glioblastoma Patient-Derived Cell Cultures to Drugs Reveals New Therapeutic OpportunitiesSemantic proximity Read ↗

Epigenetic pathways and glioblastoma treatmentSemantic proximity Read ↗

Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.Semantic proximity Read ↗

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastomaSemantic proximity Read ↗

Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.