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DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas

2 Jun 2016

Abstract excerpt

PURPOSE: DNA methylation is a heritable covalent modification that is developmentally regulated and is critical in tissue-type definition. Although genotype-phenotype correlations have been described for different subtypes of renal cell carcinoma (RCC), it is unknown if DNA methylation profiles correlate with morphological or ontology based phenotypes. Here, we test the hypothesis that DNA methylation signatures...

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PMID: 27256309
DOI: 10.1158/1078-0432.ccr-15-1217

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