Article
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
Nature genetics - 1 Jan 2015
Durinck Steffen, Stawiski Eric W, Pavía-Jiménez Andrea, Modrusan Zora, Kapur Payal, Jaiswal Bijay S, Zhang Na, Toffessi-Tcheuyap Vanina, Nguyen Thong T, Pahuja Kanika Bajaj, Chen Ying-Jiun, Saleem Sadia, Chaudhuri Subhra, Heldens Sherry, Jackson Marlena, Peña-Llopis Samuel, Guillory Joseph, Toy Karen, Ha Connie, Harris Corissa J, Holloman Eboni, Hill Haley M, Stinson Jeremy, Rivers Celina Sanchez, Janakiraman Vasantharajan, Wang Weiru, Kinch Lisa N, Grishin Nick V, Haverty Peter M, Chow Bernard, Gehring Julian S, Reeder Jens, Pau Gregoire, Wu Thomas D, Margulis Vitaly, Lotan Yair, Sagalowsky Arthur, Pedrosa Ivan, de Sauvage Frederic J, Brugarolas James, Seshagiri Somasekar
Abstract excerpt
To further understand the molecular distinctions between kidney cancer subtypes, we analyzed exome, transcriptome and copy number alteration data from 167 primary human tumors that included renal oncocytomas and non-clear cell renal cell carcinomas (nccRCCs), consisting of papillary (pRCC), chromophobe (chRCC) and translocation (tRCC) subtypes. We identified ten significantly mutated genes in pRCC, including MET,...
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