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Article

Dysregulated cholesterol regulatory genes as a diagnostic biomarker for cancer

21 Jan 2023

Abstract excerpt

BACKGROUND: A dysregulation of cholesterol homeostasis is often seen in various cancer cell types, and elevated cholesterol content and that of its metabolites appears to be crucial for cancer progression and metastasis. Cholesterol is a precursor of various steroid hormones and a key plasma membrane component especially in lipid-rafts, also modulating many intracellular signaling pathways. METHODS: To provide an...

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PMID: 36670344
DOI: 10.1002/jgm.3475

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