A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.

doi:10.1016/j.ccr.2010.01.022

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Article

A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.

Cancer cell - 13 Apr 2010

Hirsch Heather A, Iliopoulos Dimitrios, Joshi Amita, Zhang Yong, Jaeger Savina A, Bulyk Martha, Tsichlis Philip N, Shirley Liu X, Struhl Kevin

Abstract excerpt

Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program, many drugs used for treatment of diabetes and cardiovascular diseases inhibit transformation and tumor growth. Unexpectedly, lipid metabolism genes are important for transformation and are upregulated in cancer...

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Identifiers

PMID: 20385360
DOI: 10.1016/j.ccr.2010.01.022
PMCID: PMC2854678

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OLR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.