Article
Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3.
Scientific reports - 20 Jan 2023
Haws William, England Samantha, Grieb Ginny, Susana Gabriela, Hernandez Sophie, Mirer Hunter, Lewis Katharine
Abstract excerpt
HMX3 is a homeodomain protein with essential roles in CNS and ear development. Homeodomains are DNA-binding domains and hence homeodomain-containing proteins are usually assumed to be transcription factors. However, intriguingly, our recent data suggest that zebrafish Hmx3a may not require its homeodomain to function, raising the important question of what molecular interactions mediate its effects. To...
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