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Article

Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010

Chen Lizhen, Zhao Peng, Wells Lance, Amemiya Chris T, Condie Brian G, Manley Nancy R

Abstract excerpt

Hox genes play evolutionarily conserved roles in specifying axial position during embryogenesis. A prevailing paradigm is that changes in Hox gene expression drive evolution of metazoan body plans. Conservation of Hox function across species, and among paralogous Hox genes within a species, supports a model of functional equivalence. In this report, we demonstrate that zebrafish hoxa3a (zfhoxa3a) expressed from...

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Identifiers

PMID: 20498049
DOI: 10.1073/pnas.1005129107
PMCID: PMC2890846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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