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Article

Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass.

BMC developmental biology - 20 Apr 2009

Munroe Robert J, Prabhu Vinay, Acland Greg M, Johnson Kenneth R, Harris Belinda S, O'Brien Tim P, Welsh Ian C, Noden Drew M, Schimenti John C

Abstract excerpt

BACKGROUND: The H6 homeobox genes Hmx1, Hmx2, and Hmx3 (also known as Nkx5-3; Nkx5-2 and Nkx5-1, respectively), compose a family within the NKL subclass of the ANTP class of homeobox genes. Hmx gene family expression is mostly limited to sensory organs, branchial (pharyngeal) arches, and the rostral part of the central nervous system. Targeted mutation of either Hmx2 or Hmx3 in mice disrupts the vestibular...

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PMID: 19379485
DOI: 10.1186/1471-213X-9-27
PMCID: PMC2676275

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