Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome.

PLoS genetics - 1 Mar 2014

Kumar P Pavan, Franklin Sarah, Emechebe Uchenna, Hu Hao, Moore Barry, Lehman Chris, Yandell Mark, Moon Anne M

Abstract excerpt

TBX3 is a member of the T-box family of transcription factors with critical roles in development, oncogenesis, cell fate, and tissue homeostasis. TBX3 mutations in humans cause complex congenital malformations and Ulnar-mammary syndrome. Previous investigations into TBX3 function focused on its activity as a transcriptional repressor. We used an unbiased proteomic approach to identify TBX3 interacting proteins in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA, Messenger
Share to Abnormalities, Multiple

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alternative Splicing

Share to Gene Expression Regulation, Developmental

Share to Mutation

Share to RNA Precursors

Share to T-Box Domain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24675841
DOI: 10.1371/journal.pgen.1004247
PMCID: PMC3967948

Genes

TBX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome.PMID 24675841Read ↗

Diverse functional networks of Tbx3 in development and disease.Semantic proximity Read ↗

A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome.Semantic proximity Read ↗

Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome.Semantic proximity Read ↗

The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndrome.Semantic proximity Read ↗

Ulnar-Mammary syndrome with TBX3 gene mutation in a Chinese family: A case report and literature review.Semantic proximity Read ↗

An inherited TBX3 alteration in a prenatal case of ulnar-mammary syndrome: Clinical assessment and functional characterization in Drosophila melanogaster.Semantic proximity Read ↗

TBX3- Related Disorder.Semantic proximity Read ↗

Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects.Semantic proximity Read ↗

The roles and regulation of TBX3 in development and diseaseSemantic proximity Read ↗

Ulnar-mammary syndrome with dysmorphic facies and mental retardation caused by a novel 1.28 Mb deletion encompassing the TBX3 gene.Semantic proximity Read ↗

Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram syndrome via association with SC35.Semantic proximity Read ↗

The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.